H. Vainio Reihenfolge der Bücher (Chronologisch)

The evaluation of potential cancer chemopreventive agents require large, long-term, randomized trials in humans. Biomarkers that would allow the identification of subjects exposed to carcinogenic agents, or of individuals genetically, susceptible to cancer would be of great value. This volume is the product of an attempt to assess current knowledge and experience with the use of biomarkers in cancer chemoprevention. It comprises an expert report on the current state of the art use of biomarkers in cancer chemoprevention, introductory sections covering general topics in cancer chemoprevention, and contributions, directed to biomarkers of exposure, intermediate effect and susceptibility relating to six major cancer sites: skin, colorectum, breast, prostate, liver, and upper aerodigestive tract.

This volume contains the papers presented at a meeting held in December 1985 to review the conduct and use of long- and short- term assays for the detection of chemical carcinogens. The meeting was attended by about 60 experts in the fields of carcinogenesis, mutagenesis, and cell biology.The series of reports on long-term carcinogenicity assays pay particular attention to three the role of pharmacokinetic data, early preneoplastic lesions in carcinogenesis, and the possibility for discerning the relative contribution of carcinogens to various stages of carcinogenesis. Thereports on short-term assays summarize, among other points, the principle and scientific basis of each assay and its relevance to carcinogen detection and to the multistage process of carcinogenesis.