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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
Buchkauf
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Sprache
- Erscheinungsdatum
- 2012
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- (Hardcover)
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- Titel
- Heteroaromatic Lipoxin A4 Analogues
- Untertitel
- Synthesis and Biological Evaluation
- Sprache
- Englisch
- Autor*innen
- Colm Duffy
- Erscheinungsdatum
- 2012
- Einband
- Hardcover
- Seitenzahl
- 152
- ISBN13
- 9783642246319
- Reihe
- Springer Theses
- Schlagwörter
- Sachbücher
- Beschreibung
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.