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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Buchkauf
PEGylated protein drugs: basic science and clinical applications, Francesco M. Veronese
- Sprache
- Erscheinungsdatum
- 2009
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- Titel
- PEGylated protein drugs: basic science and clinical applications
- Sprache
- Englisch
- Autor*innen
- Francesco M. Veronese
- Verlag
- Birkhäuser
- Erscheinungsdatum
- 2009
- ISBN10
- 3764386789
- ISBN13
- 9783764386788
- Kategorie
- Medizin & Gesundheit
- Beschreibung
- PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.