Fluxgate-Magnetrelaxometrie magnetischer Nanopartikel in der Bioanalytik

Autor*innen

• Erik Alexander Heim

Parameter

• Lehrbücher
• Universitätslehrbücher

Mehr zum Buch

Magnetic nanoparticles have significant applications in medicine and biotechnology, notably as contrast agents for magnetic resonance imaging and in the separation and purification of biomolecules. Tailoring these nanoparticles for specific applications requires precise control over their size, distribution, and functionalization for target binding. In bioanalytics, the superparamagnetic properties enable the detection of biomolecules through magnetic moment alignment in a magnetic field. When the field is removed, the moments relax randomly, with the decay rate influenced by nanoparticle mobility, which varies upon target binding, allowing for quantification of targets. A highly sensitive measurement system was developed to assess magnetic relaxation at room temperature, eliminating the need for expensive cooling and shielding. This system includes coils for sample magnetization and integrated fluxgate magnetometers to measure stray fields, enhancing signal-to-noise ratios through a differential arrangement. Specialized coil electronics and software applications were created for measurement control and data analysis, determining measurement uncertainty and detection limits for small quantities of nanoparticles and biomolecules. The system facilitated binding experiments and kinetics studies of superparamagnetic nanoparticles. Additionally, a laboratory instrument was developed to integrate the measurement system and electr

• Sprache: Deutsch
• Erscheinungsdatum: 2009