Down syndrome and related developmental disorders

Down syndrome and Fragile X syndrome are two of the most common developmental disorders of the nervous system in humans. Now that animal models can reliably reproduce many of the phenotypes of these disorders, it has become possible to elucidate the nature of the biological mechanisms that are involved in these two syndromes and new therapeutic options have potentially become available. Highlighting the past, present and future research and the treatment of Down syndrome and Fragile X syndrome, this special topic issue provides a collection of primary research and review articles by leading experts in the field. The broad scope of the articles will be of great interest to both researchers and clinicians in the field of neurodevelopmental disorders.