Extracellular matrix

Autor*innen

• Nikos K. Karamanos

Parameter

• Medizin & Gesundheit

Mehr zum Buch

In recent decades, cell biology and biological chemistry have focused on the intricate network of macromolecules in the space between cells, which is vital for structural support, cell adhesion, and signaling. This comprehensive handbook on the extracellular matrix offers an overview of matrix components, their structures and functions, and their roles in health and disease, including matrix pathobiology and pharmacological targeting. It introduces the extracellular matrix and includes detailed sections on its importance in health and disease, matrix proteoglycans (such as aggrecan and versican), matrix proteinases involved in remodeling and wound healing, and the role of glycobiology in cancer and inflammation. Additionally, it covers collagens, cell surface receptors like integrins and syndecans, and the impact of mechanical strain and growth factors on matrix regulation. The book also discusses biotechnological and pharmacological perspectives, including disease targeting and delivery systems. This collection of relevant topics provides a thorough understanding of the extracellular matrix and its interactions with cells in both normal and diseased tissues, serving as a valuable reference for current research and applications in the field.

• Sprache: Englisch
• Erscheinungsdatum: 2012
• Einband: Hardcover