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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Buchkauf
Resistance to Molecular Therapies for Hepatocellular Carcinoma, Augusto Villanueva
- Sprache
- Erscheinungsdatum
- 2018
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- Titel
- Resistance to Molecular Therapies for Hepatocellular Carcinoma
- Sprache
- Englisch
- Autor*innen
- Augusto Villanueva
- Verlag
- Springer
- Verlag
- 2018
- ISBN10
- 3319858505
- ISBN13
- 9783319858500
- Kategorie
- Medizin & Gesundheit
- Beschreibung
- This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.