Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
Autoren
Mehr zum Buch
The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.
Buchkauf
Female sex and ER-alpha modulate cardiac ischaemic remodeling, Xiang Zhang
- Sprache
- Erscheinungsdatum
- 2017
- product-detail.submit-box.info.binding
- (Paperback)
Lieferung
Zahlungsmethoden
Feedback senden
- Titel
- Female sex and ER-alpha modulate cardiac ischaemic remodeling
- Untertitel
- Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
- Sprache
- Englisch
- Autor*innen
- Xiang Zhang
- Erscheinungsdatum
- 2017
- Einband
- Paperback
- Seitenzahl
- 92
- ISBN13
- 9783838151281
- Kategorie
- Medizin & Gesundheit
- Beschreibung
- The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.