International Program on Chemical Safety Reihenfolge der Bücher (Chronologisch)

This practical guide focuses on laboratory analysis for over 100 substances commonly involved in acute poisoning cases. Recognizing that many hospitals, particularly in developing countries, lack analytical toxicology services, it aims to assist laboratory staff in conducting simple tests that yield rapid and reliable results for managing poisoning emergencies. The tests require no sophisticated equipment, expensive reagents, or constant electricity. The manual begins with general information about the organization and functions of an analytical toxicology laboratory, emphasizing safe laboratory practices and the essentials of emergency medicine and intensive care that impact laboratory operations. The core of the manual consists of two chapters detailing simple analytical tests for detecting and identifying poisons in biological fluids or materials found near patients. The first chapter outlines a three-part series of qualitative tests designed for routine, rapid screening, particularly useful when the poison's identity is unknown. The second, more extensive chapter offers step-by-step instructions for qualitative tests and some quantitative methods for 113 specific poisons or groups of poisons. The substances covered range from pesticides and industrial chemicals to household products, pharmaceuticals, plant toxins, and commonly abused drugs.

This volume contains the papers presented at a meeting held in December 1985 to review the conduct and use of long- and short- term assays for the detection of chemical carcinogens. The meeting was attended by about 60 experts in the fields of carcinogenesis, mutagenesis, and cell biology.The series of reports on long-term carcinogenicity assays pay particular attention to three the role of pharmacokinetic data, early preneoplastic lesions in carcinogenesis, and the possibility for discerning the relative contribution of carcinogens to various stages of carcinogenesis. Thereports on short-term assays summarize, among other points, the principle and scientific basis of each assay and its relevance to carcinogen detection and to the multistage process of carcinogenesis.