Volume 2 delves into the dynamic research surrounding nickel and its complexes in Nature. Featuring over 2800 references and 130 illustrations, it serves as a crucial resource for scientists across fields from inorganic biochemistry to medicine. Comprising 17 chapters authored by 47 experts, it emphasizes the biogeochemistry of nickel, its environmental roles, and its significance in plants, cyanobacteria, and the gastric pathogen Helicobacter pylori, as well as its influence on gene expression and carcinogenesis. The text explores nickel's complex-forming abilities with amino acids, peptides, phosphates, nucleotides, and nucleic acids. It also provides insights into recent advancements in understanding nickel's role in various enzymes, including ureases, hydrogenases, and superoxide dismutases, while revealing the chaperones involved in nickel metabolism. The volume begins with the biogeochemistry of nickel and its environmental release from both natural and anthropogenic sources, highlighting the importance of atmospheric distribution. Subsequent chapters address nickel's effects on cyanobacteria and eukaryotic plant metabolism, including deficiency and toxicity, and discuss the use of nickel hyperaccumulator plants for phytomining and phytoremediation. The formation of nickel complexes with amino acids, peptides, and other biomolecules is also summarized, considering intramolecular equilibria and comparisons with related me
