Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Autor*innen

• Colm Duffy

Reihen

• Springer Theses

Parameter

• 152 Seiten
• 6 Lesestunden

• Sachliteratur

Mehr zum Buch

Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.

• Sprache: Englisch
• Erscheinungsdatum: 2014
• Einband: Paperback