Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Autor*innen

• Colm Duffy

Reihen

• Springer Theses

Parameter

• 152 Seiten
• 6 Lesestunden

• Sachliteratur

Mehr zum Buch

Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.

• Sprache: Englisch
• Erscheinungsdatum: 2012
• Einband: Hardcover